STEM CELLS PREVENT LONG-TERM DETERIORATION OF RENAL FUNCTION AFTER RENAL ARTERY REVASCULARIZATION IN A RENOVASCULAR HYPERTENSION MODEL IN RATS

Stem cells prevent long-term deterioration of renal function after renal artery revascularization in a renovascular hypertension model in rats

Abstract Partial stenosis of the renal artery causes renovascular hypertension (RVH) and is accompanied by chronic renal ischemia, resulting in irreversible kidney damage.Revascularization constitutes the most efficient therapy for normalizing blood pressure (BP) and has significant benefits for renal function; however, the tissue damage caused by

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An oncolytic vaccinia virus encoding hyaluronidase reshapes the extracellular matrix to enhance cancer chemotherapy and immunotherapy

Background The redundant extracellular matrix (ECM) within tumor microenvironment (TME) such as hyaluronic acid (HA) often impairs intratumoral dissemination of antitumor drugs.Oncolytic viruses (OVs) are being studied extensively for cancer therapy either alone or in conjunction with chemotherapy and immunotherapy.Here, we designed a novel recombi

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